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That initial discoverywhere dialysate from sleeping rabbits actually triggered sleep in recipient animalskicked off decades of study into how this peptide helps regulate sleep cycles

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doi: 10.3389/fimmu.2013.00129 92 AllavenaPSicaAGarlandaCMantovaniA

Superimposing a tonic pharmacological brake on top of this feedback system creates competing signals, and it would be unsurprising if intestinal feedback partially normalized emptying over time even while the drug is present